Systems Biology: An Introduction to Metabolic Control Analysis

To order the book in print, please select one of the following:

Amazon (USA, Europe, Asia)

This is an introductory book on metabolic control analysis available as of August 30th, 2018. Page content: 275 pages, 118 Illustrations, 71 Exercises. Retail Price $49.95.

A full-color version of the book in pdf form is also available from Gumroad:

PDF Version $7.95 available from Gumroad.


This book is an introduction to control in biochemical pathways. It introduces students to some of the most important concepts in modern metabolic control. It covers the basics of metabolic control analysis that helps us think about how biochemical networks operate. The book should be suitable for undergraduates in their early to mid-years at college.


  1. Traditional Concepts in Metabolic Regulation

  2. Elasticities

  3. Introduction to Biochemical Control

  4. Linking the Parts to the Whole

  5. Experimental Methods

  6. Linear Pathways

  7. Branched and Cyclic Systems

  8. Negative Feedback

  9. Stability

  10. Stability of Negative Feedback Systems

  11. Moiety Conservation Laws

  12. Moiety Conserved Cycles

Appendix A: List of Symbols and Abbreviations

Appendix B: Control Equations